得克萨斯大学西南医学中心张召课题组招聘博士后

得克萨斯大学西南医学中心张召课题组招聘博士后

张召课题组位于德州大学西南医学中心（UT Southwestern Medical Center）的宿主防御遗传学中心（Center for the Genetics of Host Defense）。该中心由诺贝尔奖获得者Bruce Beutler博士创立，并开发了世界上最大的小鼠正向遗传学诱变筛选平台。张召课题组的研究方向为代谢类疾病的分子机制，最终目标为将这些分子机制转化为代谢类疾病的治疗方案。目前课题组已经筛选了一半以上的小鼠基因组，鉴定出数十种新的导致肥胖，糖尿病，脂肪肝的突变小鼠并研究其分子机制。课题组研究的多为功能未知的新基因和不同于常规的新代谢表型。实验室成立两年来，已以第一作者和通讯作者在Nature Communications （PMID: 35842425），Cell Metabolism（PMID: 36228616）等杂志发表研究论文。目前，实验室的资助来源包括美国国立卫生研究院（R00，R01）和西南医学中心的启动资金。现招聘博士后一名，详情请见实验室网站（https://labs.utsouthwestern.edu/zhang-zhao-lab）和下述英文招聘简介：

Postdoctoral Position in Molecular Mechanisms of Metabolic Diseases

A postdoctoral position is available in the laboratory of Dr. Zhao Zhang, in the Center for the Genetics of Host Defense at UT Southwestern Medical Center to study molecular mechanisms of metabolic diseases.

Established in 2020, the Zhang laboratory employs a unique mouse forward genetic screening approach to identify new regulators of major metabolic diseases, including obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD). We use various approaches, including biochemistry, cell biology, molecular biology, proteomics, and mouse models to study the molecular mechanisms. Our laboratory has several exciting projects related to: 1) The dynamic regulation of a newly identified E3 ubiquitin ligase in insulin signaling. 2) The role of several new genes in the regulation of obesity. 3) The mechanism of several new genes in the pathogenesis of NAFLD. The research in our laboratory is funded by CGHD and several NIH grants (K99, R00, R01). For more details, please visit our lab website at https://www.utsouthwestern.edu/labs/zhang-zhao/.

Candidates must hold a doctoral degree (Ph.D. and/or M.D.) or scheduled to receive a doctoral degree very soon, and should be highly motivated. Experience in cell signaling, mouse genetics, fatty liver disease, obesity, and diabetes research leading to publication in peer-reviewed journals is recommended. Information on our postdoctoral training program and benefits can be found in our Postdoc Handbook or at http://www.utsouthwestern.edu/postdocs.

Interested individuals should send a CV, statement of interests, and a list of three references to:

Zhao Zhang, Ph.D.

Assistant Professor

UT Southwestern Medical Center

5323 Harry Hines Blvd.

Dallas, TX 75390-8505

Zhao.Zhang@UTSouthwestern.edu

转自：“iNature”微信公众号

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