美国MD Anderson癌症中心马莉教授团队招聘博士后
Position/Program Description:Postdoctoral positions are immediately available to work in the area of metastasis and cancer therapy resistance. The PI and colleagues have conducted seminal and impactful research on tumor metastasis (e.g., Nature 2007, Nature Cell Biology 2010, Nature Biotechnology2010, Nature Medicine 2012, Cancer Research 2016, Nature Genetics 2018) and cancer therapy resistance, including radioresistance (e.g., Nature Cell Biology2014, Nature Communications 2014, Nature Communications 2021), small-molecule inhibitor resistance (Cell Reports 2018, Nature Communications 2021), and immunotherapy resistance (Nature Communications 2021).
The approaches we take range from biochemistry, molecular biology, and cell biology to mouse genetics. Examples of current projects are using genetically engineered mouse models to study (1) noncoding RNA functions in homeostasis and metastasis; (2) the role of an iron-sequestering pathway in cancer progression and therapy resistance; and (3) cell-autonomous mechanisms and immune regulation of tissue repair and regeneration. Moreover, we recently developed an in vivo positive selection system by using a next-generation forward genetics approach, and our screens identified novel metastasis driver genes.
We are curiosity-driven scientists who aim to make discoveries that will advance science and improve human health, and we and others are seeking clinical translation of our original findings.
Here is an example of a lead therapeutic candidate being designed to treat metastatic cancers based on our initial discovery: https://www.transcodetherapeutics.com/ttx-mc138.html
Learning Objectives:To obtain training on mouse models, metastasis, and cancer therapy resistance, to publish projects in high-impact research journals, and to learn scientific writing, presentation, and management skills before applying for tenure-track faculty positions.
Eligibility Requirements:An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research and scholarship in preparation for a research career as an independent investigator. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in cancer biology and translational collaborations.
Stipend:Paid based on the NIH NRSA stipend levels.
Additional Application Information:We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. We have a track record of training the best and the brightest postdoctoral fellows who have landed independent faculty positions, and several of them have obtained independent funding as the PI and published last, corresponding-author research papers in leading journals (e.g., Nature Communications 2022).
Contact Information:Li Ma, Ph.D.,Professor, MD Anderson Cancer CenterLMa4@mdanderson.org
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