课题组简介
陈子博实验室为生物编程实验室，我们的研究重点是通过从头设计蛋白质和蛋白质回路，使它们编码信息并在试管和细胞中对生物行为进行编程。实验室的研究项目从基础问题到实际应用，大致可以分为以下两个方向：
1. 使用蛋白质进行分子计算。我们设计蛋白质回路，使其在细胞内外进行可编程、高鲁棒性的计算，并且可预测地控制细胞功能。电路组件是使用Rosetta从头设计的蛋白质，以便在单分子水平上完全定制其功能。
2. 蛋白质的可编程自组装。自然界中的蛋白质能自组装成对细胞功能至关重要的三维多聚体结构。在大多数情况下，控制此类组装的“算法”写在相邻蛋白质之间的局部相互作用中，从而允许复杂结构从简单的构建块中自主产生。我们从头设计类似的蛋白质，使其自组装成可自定义的多聚体结构，从而提供通用的超分子结构基序来控制和改变细胞功能。
招聘岗位
1.助理研究员
2.科研助理
3.博士后
应聘条件
1. 专业要求：包括但不限于生物学、计算机科学、电气工程、物理学、材料科学和化学等。
2. 有强烈的好奇心和足够的科研热情。
薪酬与福利待遇
根据西湖大学相关规定以及申请人工作能力，实验室将提供在国内外极具竞争力的薪酬待遇以及科研条件，享受五险一金及西湖大学的相关福利。
应聘方式
请参见https://chenlab.org/page/join-us（点击文末“阅读原文”即可访问），并将英文申请材料以PDF附件形式发送至zibochen@westlake.edu.cn。
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Multiple positions in The Chen Lab, School of Life Sciences
The focus of the Chen group is to program biological behaviors by designing de novo proteins and protein circuits that encode information and collectively carry out user-defined computations in test tubes and living cells. Research projects in the lab span from fundamental questions to real-world applications, and can be broadly classified into the following directions:
1. Molecular Computing with Protein Circuits. We design protein-based circuits that programmably and robustly carry out computations both inside and outside of cells, enabling one to predictably control cell functions. Circuit components are proteins designed from scratch using Rosetta, which allows full customization of their functionalities at the single molecule level.
2. Programmable Self-assembly of Proteins. Proteins in nature self-assemble into cages, fibers, sheets, and crystals that are critical to cellular functions. In most cases, the algorithms governing such assemblies are embedded in local interactions between adjacent proteins, allowing complex structures to autonomously arise from simple building blocks. We design information-bearing proteins that programmably assemble into desired shapes, which can provide versatile supramolecular structure motifs to study and alter cellular functions.
Job Openings
1.Research scientists
2.Research technicians
3.Postdoctoral Fellows
Job Requirements
We welcome people with diverse backgrounds, including but not limited to biology, computer science, electrical engineering, physics, materials science, and chemistry. The only requirement is to be curious and motivated.
Compensation and Benefits
The research team offers an internationally competitive compensation package commensurate with the selected candidate’s qualifications and experience.
How to apply
To apply, please see https://chenlab.org/page/join-us, and send application materials in English to zibochen@westlake.edu.cn.
转自： iNature
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