研究领域：
抗癌基因在维持基因组稳定性，调节肿瘤代谢及肿瘤免疫中的作用；肿瘤发生发展与转移的单细胞多组学研究。
代表性研究成果：
1. Yin, Y., Tainsky, M. A. Bischoff, F. A., Strong, L. C. and Wahl, G. M. (1992). Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70: 937-948.
2. Yin, Y., Terauchi, Y., Solomon, G. G., Aizawa, S., Rangarajan, P. N., Yazaki, Y., Kadowaki, T, and Barrett, J. C. (1998). Involvement of p85 in p53-dependent apoptotic response to oxidative stress. Nature 391: 707-710.
3. Yin, Y.*, Liu, Y. X., Jin, Y. J., Hall, E. J., and Barrett, J. C. (2003). PAC1 phosphatase is a transcription target of p53 in signaling apoptosis and growth suppression. Nature 422: 527-531.
4. Shen, W. H., Balajee, A. B., Wang, J., Wu, H., Eng, C., Pandolfi, P. P., and Yin, Y.* (2007). Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell, 128: 157-170.
5. Liang, H., He, S., Yang, J., Jia, X., Wang, P., Chen, X., Zhang, Z., Zou, X., McNutt, M. A., Shen, W. H.,* and Yin, Y.*. (2014). PTENα is a PTEN isoform Translated through Alternative Initiation and Regulates Mitochondrial Function. Cell Metab. 19, 836-848.
6. Wang, G., Li, Y., Wang, P., Liang, H., Cui, M., Zhu, M., Guo, L., Su, Q., Sun, Y., McNutt, M. A., and Yin, Y.*. (2015). PTEN regulates RPA1 and protects DNA replication forks. Cell Res. 25, 1189-1204.
7. Lu, D., Liu, L., Ji, X., Gao, Y., Chen, X., Liu, Y., Liu, Y., Zhao, X., Li, Y., Li, Y., Jin, Y., Zhang, Y., McNutt, M. A., and Yin, Y.*(2015).The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation. Nat Immunol., 16, 1263-1273.
8. Lu, D., Liu L, Sun Y, Song J, Yin Q, Zhang G, Qi F, Hu Z, Yang Z, Zhou Z, Hu Y, Zhang L, Ji J, Zhao X, Jin Y, McNutt MA, Yin, Y.*(2020). The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity. Nat Immunol., 21, 287-297.
9. Wang, G., Qiu, M., Xing, X., Zhou, J., Yao, H., Li, M., Yin, R., Hou, Y., Li, Y., Pan, S., Huang, Y., Yang, F., Bai, F., Nie, H., Di, S., Guo, L., Meng, Z., Wang, J., Yin, Y*. (2022). Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis. Sci Transl Med., 14(630): eabk2756.
10. Zheng L, Liang H, Zhang Q, Shen Z, Sun Y, Zhao X, Gong J, Hou Z, Jiang K, Wang Q, Jin Y, Yin, Y*. (2022). circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling. Mol Cancer. 21(1): 41.
