01
导师介绍
王杨副教授，博士生导师，山东省泰山学者青年专家。2008年本科毕业于中国农业大学，同年保送至北京大学化学与分子工程学院，2013年在北京大学获得有机化学博士学位（导师：席振峰院士，张文雄教授）。之后获得欧盟“玛丽居里”学者计划，在瑞士洛桑联邦理工学院（epfl）从事博士后研究（导师：jieping zhu教授）。2017年至2019年在加拿大西蒙弗雷泽大学（sfu）从事博士后研究（导师：robert britton教授）。在有机化学、药物化学领域具有丰富的经验。在science、chem. soc. rev.、j. am. chem. soc.、angew. chem. int. ed.、acs catal.、chem. sci.、green chem.等国际顶尖学术期刊上发表具有重要影响力的学术论文20余篇。获得授权专利3项。
研究方向：有机合成方法学、药物合成
已发表论文：
1. xinyu zhang, yuan pan, tao liu, yang wang.* a facile synthesis of 1,3,4-benzotriazepinones from isatoic anhydrides and hydrazonyl chlorides. j. org. chem. 2023, 88, 7504. (if: 4.198)
2. hao dong, yongxing zhang, xiaochen tian, ruochen pang, weiwu ren, yang wang.* catalyst-free and oxidant-free tandem aza-mannich/cyclization/aromatization of c,n-cyclic azomethine imines with enamides: facile synthesis of 5,6-dihydropyrazolo[5,1-a]isoquinolines. green chem. 2022, 24, 5508. (if: 11.034)
3. lesong li, tao liu, weiwu ren, yang wang.* catalyst-free and atom-economical [4+3] cycloaddition of azadienes with cyclic azomethine imines for facile synthesis of 1,2,4-triazepines. green synth. catal. 2022, doi:10.1016/j.gresc.2022.10.010.
4. fengbiao luo, hao dong, weiwu ren,* yang wang.* organocatalytic asymmetric synthesis of tetrahydroquinolines from ortho-aminophenyl para-quinone methides. org. lett. 2022, 24, 7727. (if: 6.072)
5. yuan pan, weiwu ren,*zhanhao zhang, fengbiao luo, xiaohan hou, xiaoyang li, yun-fang yang, yang wang.* tandem 1,6-addition/cyclopropanation/rearrangement reaction of vinylogous para-quinone methides with 3-chlorooxindoles: construction of vicinal quaternary carbon centers.org. chem. front. 2022, 9, 3697. (if: 5.456)
6. xiaochen tian, yongxing zhang, hao dong, weiwu ren,* yang wang.* asymmetric α‑regioselective [3 + 2] annulation of morita−baylis−hillman carbonates: construction of three contiguous stereocenters with vicinal quaternary carbon centers. j. org. chem. 2022, 87, 9593. (if: 4.198)
7. xiaochen tian, yongxing zhang, weiwu ren, yang wang.* synthesis of functionalized 3,2'-pyrrolidinyl spirooxindoles via domino 1,6-addition/annulation reactions of para-quinone methides and3-chlorooxindoles. org. chem. front. 2022, 9, 615. (if: 5.456)
8. lesong li, tao liu, xiaoli zhang, xiaohan hou, hao dong, xiaoyang li, weiwu ren, yang wang.* catalyst-free and atom-economical 1,3-dipolar cycloaddition of c,n-cyclic azomethine imines: facile synthesis of isoquinoline-fused spirocycles. green synth. catal. 2022,2, 69.
9. xiaochen tian, xiaoli zhang, xiaohan hou, weiwu ren, xiaoyang li, fei zhao, houchao tao, yang wang.* formal [4+1] cyclization of ortho- or para-quinone methides with3-chlorooxindoles: synthesis of 3,2’-tetrahydrofuryl spirooxindoles. asian j. org. chem. 2021, 10, 2385. (if: 3.116)
10. roger a. ashmus, yang wang (co-first author), manuel gonzález-cuesta, dustin t. king,ben tiet, pierre-andré gilormini, a josé m. garcía fernández, carmen ortiz mellet, robert britton,* david j. vocadlo.* rational design of cell active c2-modified dgj analogues for the inhibition of human α-galactosidase a (gala). org. biomol. chem. 2021, 19, 8057. (if: 3.890)
11. michael meanwell, steven m. silverman, johannes lehmann, bharanishashank adluri, yang wang, ryan cohen, louis-charles campeau, robert britton.* a short de novo synthesis of nucleoside analogs. science 2020, 369, 725. (if: 63.714)
12. yang wang,* wen-xiong zhang,* zhenfeng xi. carbodiimide-based synthesis of n-heterocycles: moving from two classical reactive sites to chemical bond breaking/forming reaction. chem. soc. rev. 2020,49, 5810. (if: 60.615)
13. yang wang,qian wang, jieping zhu.* organocatalytic nucleophilic addition of hydrazones to imines: synthesis of enantioenriched vicinal diamines. angew. chem. int. ed. 2017, 56, 5612-5615.(if: 16.823)
14. yang wang, qian wang, jieping zhu.* chiral phosphoric acid-catalyzed enantioselective formal [3+2] cycloaddition of azomethine imines with enecarbamates. chem. eur. j. 2016, 22, 8084-8088. (if: 5.020)
15. yang wang, fei zhao, yue chi, wen-xiong zhang,* zhenfeng xi.substituent-controlled selective synthesis of n-acyl 2-aminothiazoles by intramolecular zwitterion-mediated c−n bond cleavage. j. org. chem. 2014, 79, 11146-11154.(if: 4.198)
16. yang wang, fei zhao, yi zhou, yue chi, zitao wang, wen-xiong zhang,* zhenfeng xi.mechanistic study on the cleavage and reorganization of c(sp3)╟h and c=n bonds in carbodiimides: synthesis of 1,2-dihydrothiopyrimidines and 2,3-dihydropyrimidinthiones via four-component coupling. chem. eur. j. 2013, 19, 10643-10654.(if: 5.020)
17. yang wang, yue chi, fei zhao, wen-xiong zhang,* zhenfeng xi. synthesis, characterization, and reactivity of n-acyl chloroformamidines: useful building blocks for construction of n-acyl-substituted 1,1-diaminoethylenes, amidines, ureas, and thioureas. synthesis 2013, 45, 347-354. (if: 2.969)
18. yang wang,yue chi, wen-xiong zhang,* zhenfeng xi.*regioselective ring expansion of 2,4-diiminoazetidines via cleavage of c╟n and c(sp3)-h bonds: efficient construction of 2,3-dihydropyrimidinesulfonamides.j. am. chem. soc. 2012, 134, 2926-2929. (if: 16.383)
19. yang wang,wen-xiong zhang,* zitao wang, zhenfeng xi.*procedure-controlled selective synthesis of 5-acyl-2-iminothiazolines and their selenium and tellurium derivatives by convergent tandem annulation.angew. chem., int. ed. 2011, 50, 8122-8126.(if: 16.823)
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博士研究生招生需求
1. 具有有机合成或者药物合成等相关背景。
2. 具有一定的有机化学理论基础和实验操作技能。
3. 在有机化学或者药物化学领域发表过sci论文。
欢迎有意向的同学发送个人简历、科研论文等相关材料至电子邮箱wangyang@ouc.edu.cn
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