阿德莱德大学招收生物化学博士

阿德莱德大学招收生物化学博士   

About the Project

Project –In-vitro mRNA transcription and capping are enzymatic processes which are usually conducted in low shear stirred reactors. To convert in-vitro mRNA transcription down to the scale suitable for personalised medicine it will need to be conducted using microfluidics or similar small-scale technology. In theory this process should be easy to replicate microfluidic channels using simple diffusional mixing. In practice macromolecules like enzymes and plasmid DNA and solutes including nucleotides deviate from simple models based on Stokes-Einstein behaviour. This project will study nonideal behaviour in microfluidic channels and create strategies for overcoming nonoptimal in-vitro mRNA transcription.

Facilities - The University of Adelaide has invested over $3 million in new Biomanufacturing and Nanoparticle Fabrication laboratories. The facility has plasmid DNA fermentation, purification (batch and continuous), lyophilisation, transcription, and microfluidic lipid nanoparticle fabrication capabilities. Analytical instruments include dynamic light scattering, differential scanning calorimetry, isothermal titration calorimetry, HPLCs, and GC-MS along with standard spectroscopy.

Supervisors - The project will have two supervisors; Prof. Robert Falconer (biopharmaceutical manufacturing), and Dr Lukas Gerstweiler (protein engineer). Robert Falconer is the principal supervisor. He has supervised successful postgraduate students at the University of Cambridge and University of Sheffield who undertook research on protein stability, liquid formulation, process development and enzyme function. The projects were usually in collaboration with industry partners.

Student requirements – We are looking for a highly motivated candidate with at least a B.Sc. or B. Eng. in Biotechnology, Biochemistry, Bioprocess/Chemical engineering or related fields. The candidate will preferably have a Master degree or work experience in a related field.

Scholarship - The University of Adelaide offers Research Scholarships of $AU 32,500 p.a., annually indexed, fully funded as part of a MRFF grant “Developing enabling technologies for manufacture of precision mRNA vaccines”.

How to Apply: If you are ready to seize this remarkable opportunity, please submit a comprehensive application including your CV, academic transcripts, and a brief paragraph introducing yourself, your motivation, and your interests to robert.falconer@adelaide.edu.au

转自：“学术橙”微信公众号

如有侵权，请联系本站删除！