宾夕法尼亚大学Dr. Fiona Simpkins 实验室招聘博士后，带薪访问学者，技术员。Simpkins Lab研究方向主要为妇科肿瘤DNA损伤相关基因靶向治疗和肿瘤免疫治疗。实验室以patient derived xenograft, patient derived organoid, primary cancer cells 和established cell lines为模型，结合genomic sequence, RNA sequence, proteomic等手段，研究克服肿瘤耐药性问题。
Simpkins Lab与多家药厂有合作，研究课题转化性很强，同时也可以发表高水平文章。之前的实验室研究成果目前有1个在phase II临床试验阶段(已完成)，1个在Phase Ib，以及1个正在进入临床审批阶段。博后将来既可以选择留在学术界发展，也可以去工业界。
Dr. Simpkins非常支持博后的职业发展，帮助博后改Proposal，之前有多个博后拿到了career development grant，有多个已经独立建组的博后。官方广告内容如下，欢迎联系。
Description
Postdoctoral Researcher, Paid Visiting Scholar, Research Specialist positions are available for a highly motivated applicant in the laboratory of Dr. Fiona Simpkins at the University of Pennsylvania.
Our focuses are to understand resistance mechanisms to targeted therapies such as DNA Damage Repair inhibitors (DDRi), to sequence DDRi with Immuno-Oncology (IO) drugs, and to identify biomarkers or response to these agents. We have developed a preclinical drug development program in the Ovarian Cancer Research Center with the goal of moving novel laboratory therapeutic discoveries into the clinic. We have developed >150 patient derived xenografts (PDX) models, patient-derived organoids, and primary tumor cultures from ovarian and endometrial cancers. These PDX models mimic the original tumors, thereby accelerating the translation of preclinical study results into clinical trials for patients. Also, we are “humanizing” our models by autologous tumor infiltrating lymphocyte (TIL) and macrophage (TAM) transfer, creating an autologous in vivo model system.
Our laboratory has close collaborations with pharmaceutical companies including AstraZeneca, Merck, REPAIR, Zentalis. Based on preclinical studies from our lab, novel combination therapies have moved to phase 1/2 clinical trials led by Dr Simpkins (e.g. ClinicalTrials.gov Identifier: NCT03462342 and GY031). We have another one drug combinations also moving into clinical trials. Dr. Simpkins strongly supports career development of postdocs, either developing an independent laboratory in academia or finding a position in industry. We provide a rich multi-disciplinary training environment in animal modeling, molecular biology, genomics, cancer biology, and immunology, and we have sufficient fundings from various sources, including NIH funding to support this. Previous trainees have been awarded with multiple grants including NIH career development K12 grant, OCRA early career grant, AACR fellowship, Rivkin award, OCRA mentored award, FWC grant, KOH grant and Harrison award.
Candidates are required to hold a PhD, or MD, or both. Expertise in cell and molecular biology is required and experience in DNA damage will be viewed favorably. The candidate must have excellent written and oral communication skills. A high level of participation in a collaborative team setting is required, with a high level of self-motivation, excellent organization and time management skills, ability to demonstrate creativity and sound judgment. Exemplary interpersonal and communication skills are preferred as the candidate is expected to work closely with bioinformatic collaborators. Further information about our lab can be found at https://www.med.upenn.edu/apps/faculty/index.php/g275/p8676551, OR https://www.med.upenn.edu/simpkins/. Interested applicants should submit a CV, a statement of research interests, and 3 reference letters to Haineng Xu at haineng@pennmedicine.upenn.edu.
Qualifications
In addition to above, the post-doc responsibilities include carrying out his/her own projects with some independence and timely submission of results for publication. The post-doc must demonstrate the ability to analyze data, present data, and write manuscripts for submission. The post-doc will serve as a lead on his/her own projects. The post-doc will be responsible to research relevant published literature relating to his/her project and present his/her research findings at national scientific conferences. The post-doc must be able to effectively collaborate with colleagues outside of the laboratory (including industry) as it relates to their projects.
Contact
Fiona Simpkins, MD
Professor
Director of Clinical & Translational Gynecologic Oncology Research Penn Medicine Health System
Ovarian Cancer Research Center
Division of Gynecology Oncology
Department of Obstetrics and Gynecology
University of Pennsylvania
3400 Civic Center Blvd, South Tower, Suite 10-176
Philadelphia, PA 19104
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