卡尔加里大学招收生物化学博士
About the Project
The GOAL of this work is to find effective ways to reduce the future burden of environmental cancers, including lung cancers caused by radioactive radon gas, air pollutants, and heavy metals in our air and water, using biology and epidemiology with a strong emphasis on knowledge implementation and science communication.
The FOCUS of this doctoral project is to understand how repetitive exposure to alpha particle radiation causes DNA mutations in our bodies that increase risk of cancer. Students working on this project will use genetic models systems (including gene-edited human cell lines and yeast) to identify molecular pathways that respond to the formation of the clustered, complex DNA damage caused by alpha particle radiation. A major goal is to understand why alpha particle induced DNA damage is challenging for cells to repair. This project also leverages atomic physics and epidemiological approaches in order to develop novel methods of assessing lifetime exposure to radon gas that can be implemented within health care systems as a new criteria for cancer screening.
Students will gain SKILLS in: cell and molecular biology, advanced microscopy, gene editing, DNA repair biology, genetics, radiation sciences, mass spectrometry, epidemiology, knowledge implementation, multivariate analysis, and science communication.
Study will be LOCATED at: The University of Calgary's Charbonneau Cancer Institute (https://charbonneau.ucalgary.ca/), which is located within the Cumming School of Medicine in Calgary, approximately 45 minutes drive from the Rocky Mountains in the province of Alberta. You can learn more about Alberta by visiting https://www.travelalberta.com/.
Applicant REQUIREMENTS: The ideal candidate should have a BSc (hons) or an MSc degree and be an author on at least one original research publication in the fields of Biology, Biochemistry, Atomic Physics, or an equivalent field. Knowledge of the DNA damage response field is a major bonus, as is familiarity with Canada and an interest in transdisciplinary approaches to problem solving. As our research interests are interdisciplinary by nature, in addition to Biology individuals with background experience in population health, epidemiology, medicine, and/or statistics will have an advantage.
IMPORTANT: An equivalent BSc Grade Point Average of 3.5 (out of 4.0) or higher is essential. In UK this would equate to a first or upper second class BSc degree. Fluency in spoken and written English is also essential.
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