塔斯马尼亚大学招收癌症生物学博士
2023/5/30 15:02:49 阅读：43 发布者：
塔斯马尼亚大学招收癌症生物学博士
About the Project
Tasmanian devils (Sarcophilus harrisii) are threatened by two independently evolved transmissible cancers, devil facial tumour disease (DFTD, first detected in 1996) and devil facial tumour 2 (DFT2, first detected in 2014). The epidemiological interactions between these two transmissible cancers have the potential to result in genetic and phenotypic adaptations, leading to an evolutionary arms race between devils and tumour lineages. Quantifying the effects of devil-tumour traits and evolutionary interactions on susceptibility or resilience to infection, and how they impact disease progression and epidemic behaviour is critical for developing enduring conservation strategies.
The project aims to build new bioinformatic tools to monitor these competing cancer outbreaks in the wild. It will focus on two populations differentially impacted by both tumours, the original population where DFT2 was first documented and has been co-circulating with DFTD for 8 years and another population at the front of DFT2 expansion. The project will harness recent advances in long-read sequencing and genomic epidemiology to capture unprecedented insights into how these tumours are transmitting, competing and evolving in real-time. This project will quantify how wild populations adapt to infectious disease outbreaks, and more specifically to carcinogenic processes, with direct benefits for species conservation and disease management.
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