一、PI简介
马智谦教授于1997年获得香港科技大学理学学士学位，于2000年获香港大学颁授理学硕士学位。2005年，于牛津大学获得博士学位。随后，他前往美国波士顿儿童医院和哈佛医学院接受博士后培训，师从克利福德·伍尔夫教授，并于2011年加入香港城市大学。马智谦教授曾获香港大学尤德爵士纪念奖学金(1997-1999)、牛津大学裘槎基金会奖学金(2001-2004)及哈佛大学奖学金(2005-2007)。
二、研究兴趣及领域
神经科学
外周和中枢神经系统再生
轴突再生
动物行为研究
转化医学
分子与细胞生物学
三、研究兴趣及方向
马教授的实验室主要通过细胞生物学、分子生物学、解剖学、动物行为和遗传学等多学科的方法，研究中枢和外周神经系统损伤后再生的内在分子机制。分别使用体外细胞培养和体内动物模型检测损伤神经元的生长能力和功能恢复。他们的最终目标是寻找促进损伤后轴突再生的新策略，并提高对神经退行性疾病的认识和治疗。
实验室有开展其它神经退行性疾病的研究包括：阿尔兹海默症（Alzheimer’s Disease），帕金森（Parkinson's disease），中风（Stroke），癫痫（Epilepsy）等
四、以往发表文章 (Selected)
1. N.P. Au, G. Kumar, P. Asthana, F. Gao, R. Kawaguchi, R.C.C. Chang, K.F. So, Y. Hau, D.H. Geschwind, G. Coppola, C.H. Ma*. (2022) Clinically relevant small-molecule promotes nerve repair and visual function recovery. npj Regenerative Medicine (accepted) (Impact factor: 10.364).
2. G. Kumar, P. Asthana, W.H. Yung, K.M. Kwan, C. Tin, C.H. Ma*. (2022) Deep brain stimulation of the interposed nucleus reverses motor deficits and stimulates production of anti-inflammatory cytokines in ataxia mice. Molecular Neurobiology (accepted) (Impact factor = 5.59).
3. Y.J. Xu, N.P. Au, C.H. Ma*. (2022) Functional and Phenotypic Diversity of Microglia: Implication for Microglia-based Therapies for Alzheimer’s Disease. Frontiers in Aging Neuroscience (accepted) (Impact factor = 5.75).
4. N.P. Au, C.H. Ma*. (2022) Neuroinflammation, Microglia and Implications for Retinal Ganglion Cell Survival and Axon Regeneration in Traumatic Optic Neuropathy. Frontiers in Immunology. 13:860070. doi: 10.3389/fimmu.2022.860070 (Impact factor = 7.561).
5. P. Asthana, G. Zhang, K.A. Sheikh, C.H. Ma*. (2021) Heat shock protein is a key therapeutic target for nerve repair in autoimmune peripheral neuropathy and severe peripheral nerve injury. Brain, Behavior, and Immunity. 91: 48-64. (Impact factor = 7.217).
6. V. B. Chine, N.P. Au, C.H. Ma*. (2019) Therapeutic benefits of maintaining mitochondrial integrity and calcium homeostasis by forced expression of Hsp27 in chemotherapy-induced peripheral neuropathy. Neurobiology of Disease 130: 104492. (Impact factor = 5.996).
7. H. Chen, K.S. Cho, T.H. Khanh Vu, C.H. Shen, M. Kaur, G. Chen, R. Mathew, M.L. McHam, A. Fazelat, K. Lashkari, N.P. Au, K.Y. Tse, Y. Li, H. Yu, L. Yang, J. Stein-Streilein, C.H. Ma, C.J. Woolf, M.T. Whary, M.J. Jager, J.G. Fox, J. Chen, D.F. Chen. (2018) Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma. Nature Communications 9:3209. (Impact factor = 14.526).
8. E.J. Cobos, C. Nickerson, F. Gao, V. Chandran, I. Bravo-Caparrós, N. Andrews, A. Latremoliere, N. Joller, P. Riva, M. Painter, C.H. Ma, T. Omura, D. H. Geschwind, G. Coppola, M. Rangachari, C.J. Woolf, M. Costigan. (2018) Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling. Cell Reports 22: 1301-1312. (Impact factor = 9.423).
9. G. Kumar, N.P. Au, E. N. Y. Lei, L. Mak, L. L. H. Chan, M. H. W. Lam, L. L. Chan, P. K. S. Lam, C.H. Ma*. (2017) Acute exposure to Pacific ciguatoxin reduces electroencephalogram activity and disrupts neurotransmitter metabolic pathways in motor cortex. Molecular Neurobiology 54: 5590-5603. (Impact factor = 5.59).
10. P. Asthana, J.S.L. Vong, G. Kumar, R.C.C. Chang, G. Zhang, K.A. Sheikh, C.H. Ma*. (2015) Dissecting the role of anti-gangliosides antibodies in Guillain-Barré syndrome: an animal model approach. Molecular Neurobiology 53: 4981-91. (Featured as Front Cover Article) (Impact factor = 5.59).
11. N.P. Au, Y. Fang, N. Xi, K.W. Lai, C.H. Ma*. (2014) Probing for chemotherapy-induced peripheral neuropathy in live dorsal root ganglion neurons with atomic force microscopy. Nanomedicine: Nanotechnology, Biology, and Medicine 10: 1323-33. (Impact factor = 6.93).
12. B.T. Lang, J. Wang, A.R. Filous, N.P. Au, C.H. Ma, Y. Shen. (2014) Pleiotropic Molecules in Axon Regeneration and Neuroinflammation. Experimental Neurology 258: 17-23. (Impact factor = 5.33).
13. Y.M. Ho, N.P. Au, K.L. Wong, C.T. Chan, W.M. Kwok, G.L. Law, K.K. Tang, W.Y. Wong, C.H. Ma, Michael Hon-Wah Lam. (2014) A Lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons. Chemical Communications 50: 4161-4163. (Featured as Front Cover Article). (Impact factor = 6.718)
14. L. Korngut, C.H. Ma, J.A. Martinez, C.C. Toth, G.F. Guo, V. Singh, C.J. Woolf, D.W. Zochodne. (2012) Overexpression of human hsp27 protects sensory neurons from diabetes. Neurobiology of Disease 47: 436-43. (Impact factor = 5.996).
15. C.H. Ma, G.J. Brenner, T. Omura, O.A. Samad, M. Costigan, P. Inquimbert, H.Y. Lin, S. Arber, G. Coppola, C.J. Woolf, and T.A. Samad. (2011) The BMP co-receptor RGMb promotes while the endogenous BMP antagonist Noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling. Journal of Neuroscience 31: 18391-400. (Impact factor = 7.271).
16. C.H. Ma*, T. Omura, E.J. Cobos, A. Latrémolière, N. Ghasemlou, G.J. Brenner, Ed van Veen, L.B. Barrett, T. Sawada, F. Gao, G. Coppola, F. Gertler, M. Costigan, D. Geschwind, C.J. Woolf*. (2011) Accelerating axonal growth produces motor recovery after peripheral nerve injury in mice. Journal of Clinical Investigation 121: 4332-47. (Impact factor = 14.152).
五、 博士生招生方向及要求
1. 具有独立开展科研工作能力；
2. 具有良好的沟通能力与英文写作能力；
3. 积极上进的科研热情，认真负责的工作态度，良好的学术道德与团队合作精神。
4. 申请者需为生物学, 生物化学, 神经科学, 生物医学, 医学等相关领域，招收人数：1-2名。
5. 英语语言成绩要求：
• 托福: 79分及以上;或者
• 雅思: 6.5及以上.
六、联系方式
有意申请者请将个人简历发送至eddiema@cityu.edu.hk（邮件中简要介绍研究经历，对于未来研究方向的设想、感兴趣的研究方向）。
单位地址：香港九龙塘达之路83号香港城市大学。
转自：学术前沿速评
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