实验室主页:
https://www.chem.pku.edu.cn/zliu/放射性药物及临床转化,中子俘获治疗,活体化学,放射化学生物学我们基于原创的活体化学和放射化学工具,解决生命科学和临床医学的前沿难题。多个原创核药物已实现转化,目前正在申请临床批件。1. Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao*, Zhibo Liu*, A Bioorthogonal System Reveals Antitumour Immune Function of Pyroptosis. Nature, 2020, 579, 421–426.
2. Jiyuan Li#, Qi Sun#, Chuanjie Lu, Han Xiao, Zhibin Guo, Dongban Duan, Zizhu Zhang, Tong Liu, Zhibo Liu*, Boron encapsulated in a liposome can be used for combinational neutron capture therapy, Nat Comm, 2022, 13: 2143.
3. Chunhong Wang, Hanyu Hong, Mengqi Chen, Zexuan Ding, Yuchen Rui, Zi-Chen Li, Zhibo Liu*, A Cationic Micelle as An In Vivo Catalyst for Tumor-Localized Cleavage Chemistry. Angew Chem Int Ed, 2021, 133, 19903–19911.
4. Dongban Duan, Hao Dong, Zhiyu Tu, Chunhong Wang, Qunfeng Fu, Junyi Chen, Hai-peng Zhong, Ping Du, Ling-Dong Sun, Zhibo Liu*, Desilylation Induced by Metal Fluoride Nanocrystals Enables Cleavage Chemistry In Vivo.J Am Chem Soc, 2021, 143, 2250–2255.
5. Qunfeng Fu, Hongyu Li, Dongban Duan, Changlun Wang, Huimin Ma, Zhibo Liu*, External Radiation–Induced Local Hydroxylation Enables Remote Release of Functional Molecules in Tumors, Angew Chem Int Ed, 2020, 132, 21730-21736.
6. Pu Zhang#, Mengxin Xu#, Jie Ding, Junyi Chen, Taiping Zhang, Li Huo*, Zhibo Liu*,Fatty acid-conjugated radiopharmaceuticals for fibroblast activation protein-targeted radiotherapy, Eur. J. Nucl. Med. Mol. Imaging, 2021, doi: 10.1007/s00259-021-05591-x
7. Mengxin Xu#, Pu Zhang#, Jie Ding, Junyi Chen, Li Huo, Zhibo Liu*, Albumin Binder–Conjugated Fibroblast Activation Protein Inhibitor Radiopharmaceuticals for Cancer Therapy. J. Nucl. Med., 2021, doi:10.2967/jnumed.121.262533
8. Zhu Li#, Ziren Kong#, Junyi Chen, Jiyuan Li, Nan Li, Zhi Yang*, Yu Wang*, Zhibo Liu*, 18F-Boramino Acid PET/CT in Healthy Volunteers and Glioma Patients, Eur. J. Nucl. Med. Mol. Imaging, 2021, in press, doi.org/10.1007/s00259-021-05212-7