以下文章来源于北京生物结构前沿研究中心 ，作者谭佳鑫
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2023.9.04~2023.9.10
CNS刊登文章
01
Nature
2023/9/06
“Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells”
在癌症和感染中，患病的细胞通过一种“从内部向外”的信号传递过程被呈现给人类的Vγ9Vδ2 T细胞，这个过程是通过结构多样的磷酸抗原（pAg）分子被识别，这些分子被内源性的丁酸脂蛋白BTN3A1的细胞内结构域感知。
来自清华大学药学院张永辉及湖北大学郭瑞庭课题组合作展示了在人类和羊驼中，多种pAg分子充当“分子胶水”，促进BTN3A1和结构类似的丁酸脂蛋白BTN2A1的细胞内结构域的异源性结合。X射线晶体学研究可视化了BTN3A1与pAg的结合形成了一个用于直接与BTN2A1结合的复合界面，各种pAg分子分别位于界面的中心，并以不同的亲和力粘合着丁酸脂蛋白。使用基于结构的分子动力学模拟、19F-NMR研究、嵌合受体工程和直接测量细胞间结合力的分析，研究者揭示了pAg介导的BTN2A1结合如何以热力学有利的方式推动BTN3A1的细胞内波动向外扩散，从而使BTN3A1能够从BTN2A1外源结构域脱离，启动T细胞受体介导的γδ T细胞激活。从实际角度来看，研究者利用分子胶水模型进行了免疫治疗设计，展示了开发人类γδ T细胞功能的小分子激活剂和抑制剂的化学原理。
原文链接
https://www.nature.com/articles/s41586-023-06525-3
Science
本周无
Cell
本周无
2023.9.04~2023.9.10
子刊刊登文章
01
Cell Research
9.04
1.“Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex”
9.06
2. “Cryo-EM structures of human organic anion transporting polypeptide OATP1B1”
02
Molecular Cell
9.07
“Cryoelectron tomography reveals the multiplex anatomy of condensed native chromatin and its unfolding by histone citrullination”
03
Nature Structural & Molecular Biology
9.07
1.“Substrate binding and inhibition of the anion exchanger 1 transporter”
9.11
2.“Molecular pathway of mitochondrial preprotein import through the TOM–TIM23 supercomplex”
04
Nature Communications
9.04
1.“O-methyltransferase-like enzyme catalyzed diazo installation in polyketide biosynthesis”
9.04
2. “Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39”
9.05
3.“Cryo-EM structure of a bacteriophage M13 mini variant”
9.05
4.“The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70”
9.06
5.“Evolutionary selection of proteins with two folds”
9.06
6.“Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR”
9.06
7.“Direct observation of tRNA-chaperoned folding of a dynamic mRNA ensemble”
9.07
8. “Multifaceted membrane interactions of human Atg3 promote LC3-phosphatidylethanolamine conjugation during autophagy”
9.07
9.“Molecular architecture and electron transfer pathway of the Stn family transhydrogenase”
9.07
10.“Intrinsically disordered CsoS2 acts as a general molecular thread for α-carboxysome shell assembly”
9.07
11.“Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β”
9.08
12.“Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein”
9.08
13.“Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis”
9.08
14.“A strategy for Cas13 miniaturization based on the structure and AlphaFold”
9.11
15. “Geometric alignment of aminoacyl-tRNA relative to catalytic centers of the ribosome underpins accurate mRNA decoding”
Science Advances
本周无
作者 | 谭佳鑫
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