哥本哈根大学招收细胞生物学博士
About the Project
We are offering a fully funded 3-year PhD fellowship for a talented and highly motivated individual interested in cellular stress responses and functional genomics which is scheduled to start 1 February 2024 or after agreement.
The employment will take place in the newly starting Haahr laboratory in the DNRF Center of Excellence, Center for Gene Expression (CGEN) within the Department of Cellular and Molecular Medicine (ICMM) at the Faculty of Health and Medical Sciences, University of Copenhagen.
About the Haahr Group and the institute
Research in the Haahr Group aims to understand molecular aspects of cellular stress responses and cell signaling pathways in human cells and how its dysregulation contributes to disease development. Particularly, we are interested in the intersection of these responses with the complex regulation of transcriptional and translational machineries and how this underpins cell and organismal fitness. To do this, we combine CRISPR-mediated genome engineering with systems-wide phenotypic mutagenesis screens as well as proteomic approaches and a broad panel of more targeted methodologies within cell biology and biochemistry to identify new factors and characterize their functional significance and mechanistic underpinnings.
The research will take place as part of CGEN, which will be located in the Maersk Tower and comprise four excellent research teams (Svejstrup Group, Bekker-Jensen Group, Gregersen Group and Haahr Group) working in close collaboration on related research topics in cell stress and gene expression.
Project description
The interplay of stress responses and reprogramming of translation is tightly linked to cell and organismal fitness and understanding the molecular mechanisms underpinning these responses remains a major challenge. Utilizing a streamlined genetic screening pipeline based on fluorescence activated cell-sorting (FACS) and ultra-deep mutagenesis in human cells (Haahr et al., Science 2022) the project aims to deepen our insights into how cellular stress responses reprograms translation and determines cell fate. Using systematic screens for quantitative molecular readouts the candidate will generate genetic roadmaps that will identify new factors and mechanisms of translation regulation during stress. Where relevant, genetic screening approaches will be complemented by mass-spectrometry-based proteomic analysis.
The biological functions and mechanistic basis of screen findings will be investigated by means of a wide range of approaches within cell and molecular biology, biochemistry, and imaging approaches. The successful candidate will also have an opportunity to take part in development and implementation of new functional genomic tools to dissect multiple aspects of cell biology.
Job description
Your key tasks as a PhD student at SUND are to:
• Carry through an independent research project under supervision.
• Write scientific articles and the PhD thesis based on your research.
• Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points.
• Participate in active and ambitious research environments including a stay at another research team (preferably abroad).
• Obtain experience with teaching or other types of dissemination related to your PhD project.
Key criteria for the assessment of applicants
Applicants must have qualifications corresponding to a Master’s degree in Molecular Biomedicine, Biochemistry, Biology, Genetics or similar (equivalent to a Danish candidate 3+2 years).
Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted.
As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database.
Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science.
Other important criteria are:
• The grade point average achieved.
• Professional qualifications relevant to the PhD project.
• Relevant laboratory experience in molecular cell biology or
The application must include the following documents in PDF format:
1. Motivated letter of application (max. one page).
2. CV incl. education, experience, language skills and other skills relevant for the position.
3. Master of Science diploma and transcript of records. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will do.
4. Publication list (if possible).
Application deadline: Sunday 3 September 2023, 23.59 p.m.
转自：“学术橙”微信公众号
如有侵权，请联系本站删除！
