以下文章来源于北京生物结构前沿研究中心 ，作者谭佳鑫
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2023.6.12~2023.6.18
CNS刊登文章
01
Cell
2023/6/15
“Structural specializations of the sperm tail”
在有性生殖的生物体中，精子活力对繁殖成功至关重要。精子运动障碍导致男性不育，发病率在全球范围内正在增加。精子是由一种基于微管的分子机器——轴突驱动的，但目前还不清楚轴突微管是如何在不同的受精环境中被修饰以支持运动的。
来自荷兰乌得勒支大学的Tzviya Zeev-Ben-Mordehai和美国华盛顿大学圣路易斯分校医学院的Rui Zhang课题组合作展示了来自海胆和牛精子的天然轴突双微管(DMTs)的高分辨率结构。研究者鉴定出60多种修饰精子DMTs的蛋白质; 至少有15种与精子有关，16种与不孕有关。通过比较不同物种和细胞类型的DMTs，研究者定义了核心微管内蛋白(MIPs)，并分析了tektin束的进化。他们发现保守的轴突微管相关蛋白(MAPs)具有独特的微管蛋白结合模式。此外，他们还发现了一种睾丸特异性丝氨酸/苏氨酸激酶，该激酶将DMTs与哺乳动物精子中的外层致密纤维联系起来。本研究为在分子水平上理解精子的进化、运动和功能障碍提供了结构基础。
原文链接
https://www.cell.com/cell/fulltext/S0092-8674(23)00576-7
Nature
本周无
Science
本周无
2023.6.12~2023.6.18
子刊刊登文章
01
Cell Research
6.13
“Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity”
02
Nature Structural & Molecular Biology
6.15
1.“Architecture of the ESCPE-1 membrane coat”
6.15
2.“Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport”
03
Nature Communications
6.12
1.“Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway”
6.12
2.“Regioselective stilbene O-methylations in Saccharinae grasses”
6.12
3.“Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design”
6.12
4.“Atomic model for core modifying region of human fatty acid synthase in complex with Denifanstat”
6.13
5.“Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b”
6.13
6.“Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis”
6.14
7.“The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification”
6.14
8.“A polyamine acetyltransferase regulates the motility and biofilm formation of Acinetobacter baumannii”
6.15
9.“Mechanistic studies of a lipase unveil effect of pH on hydrolysis products of small PET modules”
6.15
10.“Molecular mechanisms of Holliday junction branch migration catalyzed by an asymmetric RuvB hexamer”
6.15
11.“Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection”
6.15
12.“Structural insight into the human SID1 transmembrane family member 2 reveals its lipid hydrolytic activity”
6.16
13.“Structure and antigenicity of divergent Henipavirus fusion glycoproteins”
6.17
14.“The inhibition mechanism of the SUR2A-containing KATP channel by a regulatory helix”
6.17
15.“Structure and proposed DNA delivery mechanism of a marine roseophage”
6.17
17.“Cannabidiol inhibits Nav channels through two distinct binding sites”
04
Science Advances
6.16
“A symmetry mismatch unraveled: How phage HK97 scaffold flexibly accommodates a 12-fold pore at a 5-fold viral capsid vertex”
Molecular Cell
本周无
作者 | 谭佳鑫
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