2022/3/3 11:43:09 阅读：410 发布者：chichi77
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药理学是研究药物与机体间相互作用规律及其药物作用机制的一门科学，主要包括药效动力学和药代动力学两个方面。前者是阐明药物对机体的作用和作用原理,后者阐明药物在体内吸收、分布、生物转化和排泄等过程,及药物效应和血药浓度随时间消长的规律。
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1. Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats
2. The baroreflex afferent pathway plays a critical role in H2S-mediated autonomic control of blood pressure regulation under physiological and hypertensive conditions
3. Tanshinone ⅡA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages
4. Engineered cardiac tissues:a novel in vitro model to investigate the pathophysiology of mouse diabetic cardiomyopathy
5. ABT-199 inhibits Hedgehog pathway by acting as a competitive inhibitor of oxysterol,rather as a BH3 mimetic
6. A brief guide to good practices in pharmacological experiments:Western blotting
7. Gut microbiota in pancreatic diseases:possible new therapeutic strategies
8. Catalpol counteracts the pathology in a mouse model of Duchenne muscular dystrophy by inhibiting the TGF-β1/TAK1 signaling pathway
9. EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers
10. Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway
11. Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest
12. DCZ5248,a novel dual inhibitor of Hsp90 and autophagy,exerts antitumor activity against colon cancer
13. Eleutheroside B,a selective late sodium current inhibitor,suppresses atrial fibrillation induced by sea anemone toxin Ⅱin rabbit hearts
14. Inhibition of the INa/K and the activation of peak INa contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs
15. Zonisamide,an antiepileptic drug,alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress
16. Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism
17. Oral administration of curcumin ameliorates pulmonary fibrosis in mice through 15d-PGJ2-mediated induction of hepatocyte growth factor in the colon
18. KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after isch
19. ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma
20. Ubiquitin-proteasome system-targeted therapy for uveal melanoma:what is the evidence?
21. Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice
22. Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation
23. DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis
24. LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK-eIF2α-ATF4-CHOP axis
25. Atomic force microscopy for revealing microanoscale mechanics in tumor metastasis:from single cells to microenvironmental cues
26. DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress
27. ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1
28. Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine
29. Species differences in the CYP3A-catalyzed metabolism of TPN729,a novel PDE5 inhibitor
30. Identification of critical molecular pathways involved in exosome-mediated improvement of cardiac function in a mouse model of muscular dystrophy
31. GJA1-20k attenuates Ang Ⅱ-induced pathological cardiac hypertrophy by regulating gap junction formation and mitochondrial function
32. Reduced intracellular chloride concentration impairs angiogenesis by inhibiting oxidative stress-mediated VEGFR2 activation
33. Targeting DNA-PK overcomes acquired resistance to third-generation EGFR-TKI osimertinib in non-small-cell lung cancer
34. Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats
35. The baroreflex afferent pathway plays a critical role in H2S-mediated autonomic control of blood pressure regulation under physiological and hypertensive conditions
36. Tanshinone ⅡA prevents LPS-induced inflammatory
