ACS Medicinal Chemistry Letters
Author Guidelines
Scope Of The Journal
Major Change: The Letters to the Editor manuscript type has been discontinued.
ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to:
Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics)
Biological characterization of new molecular entities in the context of drug discovery
Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc.
Novel and improved methodologies with broad application to medicinal chemistry
Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources
Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response
Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic
Mechanistic drug metabolism and regulation of metabolic enzyme gene expression
Chemistry patents relevant to the medicinal chemistry field
For more information, please see the journal website.
Manuscript Types
ACS Medicinal Chemistry Letters is an online publication that publishes original research in the form of Letters, Notes, and Technology Notes. The journal also invites publications that highlight recent and/or highly innovative developments in medicinal chemistry in the form of Viewpoints and Innovations. The Editors strongly encourage dialogue within the medicinal chemistry community this form of communication can be made in the form of Letters to the Editor. Descriptions of the aforementioned submission types are as follows:
Letters. Peer-reviewed reports of original research focused on an individual finding significant to a broad medicinal chemistry field.
Notes. Brief peer-reviewed reports of original research intended for the rapid dissemination of highly notable findings where existing limitations may preclude further development at the time of publication.
Technology Notes. Peer-reviewed descriptive manuscripts outlining new or improved "toolbox" innovations encompassing a myriad of technologies (high-throughput/high-content screening, robotics, structure-based drug design, fragment-based drug design, combinatorial chemistry/parallel synthesis, etc.), which simultaneously facilitate and partially define modern medicinal chemistry.
Innovations. May include articles intended to tell the backstory of drug discovery campaigns relating to the development of new therapeutic agents or articles covering the discovery and development of new technologies that enable the identification of new therapeutic targets or advancement and acceleration of drug discovery programs. See the first published Innovations article as an example.
Topical Innovations are short, timely reviews of a topic of high interest to the medicinal chemistry community. Emphasis should be on a focused topic that is instructive, rather than comprehensive, so that a medicinal chemistry audience may understand the importance of the topic and next steps that will move the field forward. Topical Innovations should include a critical evaluation of the work they review. Topics can include inter alia specific sub-disciplines of medicinal chemistry, including development of new technologies that enable identification of new therapeutic targets or advancement and acceleration of drug discovery programs. Topical Innovations should include a single unnumbered high-resolution image without caption that is 7 in. wide x 9 in. high (vertical), 7 in. high x 9 in. wide (horizontal) or 504 pt x 648 pt. This or another graphic will serve as the TOC graphic.
Viewpoints. Invited general commentaries on current issues in the medicinal chemistry field, including views on new chemical patents and relevant patent laws and tutorials of immediate interest to the broad readership.
Patent Highlights. A journal section dealing with recently issued medicinal chemistry patents. The coverage will feature patents and published patent applications in high-interest areas with brief commentaries on their potential impact. The Patent Highlights are written by members of the Patent Panel appointed by the Editors and are not open to submission by other authors.
The following list summarizes the publication and formatting requirements for ACS Medicinal Chemistry Letters manuscript types.
Letters: 4500 words, ≤150 word abstract, 6-10 figures/tables, ~40 references, peer reviewed
Notes: 2500 words, ≤150 word abstract, 2-4 figures/tables, ~30 references, peer reviewed
Technology Notes: 4500 words, ≤150 word abstract, 6-10 figures/tables, ~40 references, peer reviewed
Innovations: 7000 words, ≤250 word abstract, <6 figures/tables, ~50 references, peer reviewed, by invitation only
Topical Innovations: 7000 words, ~250 word abstract, one graphic (see details above) ~50 references, peer-reviewed
Viewpoints: 2000 words, ~50 word abstract, 0-2 figures/tables, 5-12 references, editorial review, by invitation only
ACS Publishing Center
While this document will provide basic information on how to prepare and submit the manuscript as well as other critical information about publishing, we also encourage authors to visit the ACS Publishing Center for additional information on everything that is needed to prepare (and review) manuscripts for ACS journals and partner journals, such as
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https://publish.acs.org/publish/author_guidelines?coden=amclct
