2022/12/13 10:27:36 阅读：522 发布者：
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复旦大学王永明课题组诚招博士后
王永明，博士生导师。2010获得柏林自由大学博士学位；2010-2013年在斯坦福大学医学院从事博士后研究；2013年至今在复旦大学生命科学学院工作。王永明课题组隶属复旦大学遗传工程国家重点实验室、遗传与发育协同创新中心，主要开发新型CRISPR工具，并进行基因治疗研究。先后获得国家青年人才计划和高层次人才计划。
应聘条件：
1、具有小鼠操作经验的博士后，有基因编辑或者心肌病背景的优先；2.发表过二区以上论文一篇。年薪40万起。
应聘方式：
有意者请将个人简历通过电子邮件发至：yonmiwang@gmail.com
基本信息：
职称：教授、博士生导师
邮箱：yonmiwang@gmail.com
地址：复旦大学生命科学学院 C623室
2001年获得兰州大学学士学位
2004年获得东北师范大学硕士学位
2010年获得柏林自由大学博士学位
2010-2013年在斯坦福大学医学院从事博士后研究
2013年至今在复旦大学生命科学学院开展独立工作
实验室链接：https://life.fudan.edu.cn/e7/3d/c28175a386877/page.htm
主要研究方向：
1、开发新型CRISPR工具；2.运用CRISPR技术进行基因治疗研究。
近年来代表性论文
1. Yao Wang, Tao Qi, Jingtong Liu, Yuan Yang, Ziwen Wang, Ying Wang, Tianyi Wang, Miaomiao Li, Mingqing Li, Daru Lu, Alex Chia Yu Chang, Li Yang, Song Gao, Yongming Wang*, Feng Lan*. A highly specific CRISPR-Cas12j nuclease enables allele-specific genome editing. Science Advances. Accepted.
2. Shuai Wang#, Chen Tao#, Huilin Mao, Linghui Hou, Yao Wang, Tao Qi, Yuan Yang, Sang-Ging Ong, Shijun Hu*, Renjie Chai*, Yongming Wang*. Identification of SaCas9 orthologs containing a conserved serine residue that determines simple NNGG PAM recognition. PLoS Biology. Accepted.
3. Jingjing Wei, Linghui Hou, Jingtong Liu, Ziwen Wang, Siqi Gao, Tao Qi, Song Gao, Shuna Sun*, Yongming Wang*. Closely related type II-C Cas9 orthologs recognize diverse PAMs. Elife. 2022 Aug 12;11:e77825.
4. Shuai Wang, Huilin Mao, Linghui Hou, Ziying Hu, Yao Wang, Tao Qi, Chen Tao, Yuan Yang, Chengdong Zhang, Miaomiao Li, Huihui Liu, Shijun Hu, Renjie Chai*, Yongming Wang*. Compact SchCas9 Recognizes the Simple NNGR PAM. Advanced Science. 2021 Dec 6;e2104789.
5. Shuhong Ma#, Wenjian Jiang#, Xujie Liu#,Wen-Jing Lu, Tao Qi, Jingjing Wei, Fujian Wu, Yun Chang, Siyao Zhang, Yabing Song, Rui Bai, Jianbing Wang, Andrew S. Lee, Hongjia Zhang*, Yongming Wang*, Feng Lan*. Efficient Correction of a Hypertrophic Cardiomyopathy Mutation by ABEmax-NG. Circulation Research. 2021 Oct 29;129(10):895-908.
6. Ziying Hu #, Chengdong Zhang#, Shuai Wang, Siqi Gao, Jingjing Wei, Miaomiao Li, Linghui Hou, Huilin Mao, Yanyan Wei, Tao Qi, Hongmao Liu, Dong Liu, Feng Lan, Daru Lu, Hongyan Wang*, Jixi Li*, Yongming Wang*. Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity. Nucleic Acids Research. 2021 Apr 19 ;49(7):4008-4019.
7. Rui Wang#, Chunyan Qian#, Yanan Pang, Miaomiao Li, You Yuang, Haijing Ma, Manying Zhao, Feng Qian, Hang Yu, Zhenping Liu, Ting Ni*, Yan Zheng*, Yongming Wang*. opvCRISPR: one-pot visual RT-LAMP-CRISPR platform for SARS-CoV-2 detection. Biosensors & Bioelectronics. 2020 Oct 26;172:112766.
8. Ziying Hu, Shuai Wang, Chengdong Zhang, Ning Gao, Miaomiao Li, Daqi Wang, Dong Liu, Huihui Liu, Sang-Ging Ong, Hongyan Wang, Yongming Wang. A compact Cas9 ortholog from staphylococcus auricularis (SauriCas9) expands the DNA targeting scope. PLoS Biology. 2020 Mar 30;18(3):e3000686.
9. Bei Wang#, Rui Wang#, Daqi Wang, Jian Wu, Jixi Li, Jichang Wang, Huihui Liu, Yongming Wang. Cas12aVDet: a CRISPR/Cas12a-based platform for rapid and visual nucleic acid detection. Analytical Chemistry. 2019 Oct 1;91(19):12156-12161.
10. Daqi Wang#, Chengdong Zhang#, Bei Wang, Bin Li, Qiang Wang, Dong Liu, Hongyan Wang, Yan Zhou, Leming Shi, Feng Lan*, Yongming Wang*. Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning. Nature Communications. 2019 Sep 19;10(1):4284.
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