Journal of Clinical and Translational Hepatology
2022年6月28日
Volume 10 Issue 3
第10卷 第3期 正式出版
封面文章
Diagram of novel MT targeted therapeutics in HBV infection
新型 MT 靶向治疗 HBV 感染示意图
封面解读
Numbers indicated putative drug targets.
(1) MAP1S inhibition/silencing,
(2) MAP1S-dependent acetylation of MTs, and
(3) MAP1S dependent autophagy. Blue lines indicate induction. Red lines indicate uppression. A red X indicates inhibition or silencing of MAP1S. Orange/yellow stars represent acetylation of MTs. HBV complete virion is shown by hexagonal capsid with green HBsAg and HBV naked capsid is shown by a brown hexagon.
HBV, Hepatitis B virus; MAPs, microtubule associated proteins; MTs, microtubules; HCC, hepatocellular carcinoma.
数字表示推定的药物目标。
(1) MAP1S 抑制/沉默，
(2) MTs 的 MAP1S 依赖性乙酰化，和
(3) MAP1S 依赖性自噬。蓝线表示感应。红线表示压制。红色 X 表示 MAP1S 的抑制或沉默。橙色/黄色星星代表 MTs 的乙酰化。 HBV 完整病毒体由带有绿色 HBsAg 的六角形衣壳显示，而 HBV 裸衣壳由棕色六角形显示。
HBV、乙型肝炎病毒； MAPs，微管相关蛋白； MTs，微管； HCC，肝细胞癌。
Contents | 内容概览
本期共发表22篇文章：包括1篇Editorial、1篇Hot Topic Commentary、13篇Original Article、6篇Review Article、1篇Case Report。
Editorial
Unraveling the Dynamic Role of Microtubules in the HBV Life Cycle
Urania Georgopoulou, John Koskinas
Doi: 10.14218/JCTH.2022.00135
Hot Topic Commentary
Acute Severe Hepatitis of Unknown Origin in Children Across the World: A 2022 Source of Concern
Lampros Chrysavgis, Evangelos Cholongitas
Doi: 10.14218/JCTH.2022.00252
Original Article
Change of Cytokines in Chronic Hepatitis B Patients and HBeAg are Positively Correlated with HBV RNA, Based on Real-world Study
Qiqi Zhang, Hui Huang, Aijun Sun, Chunyan Liu, Zhidong Wang, Feifan Shi, Wei Duan, Xueying Sun, Qi Wang, Ping Sun, Chunwen Pu, Yong Zhang
Doi: 10.14218/JCTH.2021.00160
Original Article
Racial and Health Disparities among Cirrhosis-related Hospitalizations in the USA
Ashwani K. Singal, Yong-Fang Kuo, Juan P. Arab, Ramon Bataller
Doi: 10.14218/JCTH.2021.00227
Original Article
Clinical Predictors of Functional Cure in Children 1–6 Years-old with Chronic Hepatitis B
Jing Pan, Haiyan Wang, Tiantian Yao, Xuejiao Liao, Hao Cheng, Suthat Liangpunsakul, Yan Wang, Min Zhang, Zheng Zhang
Doi: 10.14218/JCTH.2021.00142
Original Article
Advantages of a Novel Model for Predicting Hepatic Fibrosis in Chronic Hepatitis B Virus Carriers Compared with APRI and FIB-4 Scores
Na-Ling Kang, Qing-Fa Ruan, De-Sheng Zhang, Xue-Ping Yu, Zhen-Ting Hu, Zhi-Min Lin, Lu-Ying Wu, Meng-Xin Lin, Zu-Xiong Huang, Jia-Ji Jiang, Yu-Rui Liu, Ri-Cheng Mao, Da-Wu Zeng
Doi: 10.14218/JCTH.2022.00098
Original Article
Impact of National Centralized Drug Procurement Policy on Antiviral Utilization and Expenditure for Hepatitis B in China
Xinyu Zhao, Min Li, Hao Wang, Xiaoqian Xu, Xiaoning Wu, Yameng Sun, Canjian Ning, Bingqiong Wang, Shuyan Chen, Hong You, Jidong Jia, Yuanyuan Kong
Doi: 10.14218/JCTH.2022.00167
Original Article
Dermcidin Enhances the Migration, Invasion, and Metastasis of Hepatocellular Carcinoma Cells In Vitro and In Vivo
Fanghua Qiu, Huajing Long, Lu Zhang, Jieyuan Liu, Zetian Yang, Xianzhang Huang
Doi: 10.14218/JCTH.2021.00108
Original Article
PNPLA3 rs738409 C>G Variant Influences the Association Between Visceral Fat and Significant Fibrosis in Biopsy-proven Nonalcoholic Fatty Liver Disease
Gang Li, Liang-Jie Tang, Pei-Wu Zhu, Ou-Yang Huang, Rafael S. Rios, Kenneth I. Zheng, Sui-Dan Chen, Hong-Lei Ma, Giovanni Targher, Christopher D. Byrne, Xiao-Yan Pan, Ming-Hua Zheng
Doi: 10.14218/JCTH.2021.00286
Original Article
Relationship between the Level of Serum Golgi Protein 73 and the Risk of Short-term Death in Patients with ALD-ACLF
Jingjing Tong, Mingjie Yao, Xiuying Mu, Leijie Wang, Xiajie Wen, Xingran Zhai, Xiang Xu, Yu Wang, Jing Chen, Xiangwei Zhai, Chongdan Guan, Fengmin Lu, Jinhua Hu
Doi: 10.14218/JCTH.2020.00133
Original Article
Development and Validation of a Nomogram for 90-day Outcome in Patients with Hepatitis B Virus-related Acute-on-chronic Liver Failure
Jun Yang, Ran Xue, Jing Wu, Lin Jia, Juan Li, Hongwei Yu, Yueke Zhu, Jinling Dong, Qinghua Meng
Doi: 10.14218/JCTH.2021.00202
Original Article
Hepatitis B Virus Induces Microtubule Stabilization to Promote Productive Infection through Upregulating Microtubule-associated Protein 1S
Yuanyue Guan, Bin Sun, Shijie Zhang, Yuan Zhuang, Yanxiang Huang, Minghua Lin, Rongling Zheng, Dexi Chen, Ying Shi, Yanjun Wang
Doi: 10.14218/JCTH.2021.00090
Original Article
Ginsenoside Rb1 Reduces D-GalN/LPS-induced Acute Liver Injury by Regulating TLR4/NF-κB Signaling and NLRP3 Inflammasome
Yimei Liu, Ninghua Liu, Yujing Liu, Hongyu He, Zhe Luo, Wenjun Liu, Nan Song, Minjie Ju
Doi: 10.14218/JCTH.2021.00072
Original Article
Hepatotoxicity Induced by Biological Agents: Clinical Features and Current Controversies
Nelia Hernandez, Fernando Bessone
Doi: 10.14218/JCTH.2021.00243
Review Article
Tumor-associated Exosomes Are Involved in Hepatocellular Carcinoma Tumorigenesis, Diagnosis, and Treatment
Hang Wang, Liang Yu, Peng Huang, Yongxu Zhou, Wangyang Zheng, Nanfeng Meng, Risheng He, Yi Xu, Tey Sze Keong, Yunfu Cui
Doi: 10.14218/JCTH.2021.00425
Review Article
Pediatric Acute Severe Hepatitis of Unknown Origin: What is New?
Jing Li, Wei Hu, Ji-Yuan Zhang, Fu-Sheng Wang
Doi: 10.14218/JCTH.2022.00247
Review Article
Update on Sphincter of Oddi Dysfunction: A Review
Jaimy Villavicencio Kim, George Y. Wu
Doi: 10.14218/JCTH.2021.00167
Review Article
Acute Hepatitis of Unknown Origin in Children: Early Observations from the 2022 Outbreak
Li-Ya Zhang, Li-Su Huang, Yu-Hang Yue, Rima Fawaz, Joseph K. Lim, Jian-Gao Fan
Doi: 10.14218/JCTH.2022.00281
Review Article
Primary Sclerosing Cholangitis and Inflammatory Bowel Disease: A Review
Teresa Da Cunha, Haleh Vaziri, George Y. Wu
Doi: 10.14218/JCTH.2021.00344
Review Article
Statin-induced Liver Injury Patterns: A Clinical Review
Leon D. Averbukh, Alla Turshudzhyan, David C. Wu, George Y. Wu
Doi: 10.14218/JCTH.2021.00271
Review Article
Neoadjuvant and Adjuvant Therapy in Intrahepatic Cholangiocarcinoma
Xing Chen, Jinpeng Du, Jiwei Huang, Yong Zeng, Kefei Yuan
Doi: 10.14218/JCTH.2021.00250
Case Report
Imaging Findings of Hepatic Ewing’s Sarcoma on Computed Tomography and Gadobenate Dimeglumine-enhanced Magnetic Resonance Imaging: A Case Report and Literature Review
Tao Lu, Wenhao Yang, Xingchao Liu, Xudan Yang, Chong Yang, Wenjia Di
Doi: 10.14218/JCTH.2021.00129
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期刊简介
Journal of Clinical and Translational Hepatology (JCTH，《临床与转化肝脏病杂志》，pISSN: 2225-0719, eISSN: 2310-8819）是由重庆医科大学附属第二医院主办，Xia & He Publishing Inc. (华誉出版社)出版的英文学术期刊，主要收录肝病领域的临床或转化相关的研究论文、综述、述评等。
2021 Impact Factor : 5.065
2021 CiteScore : 6.4
转自：华誉学术
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