2022.11.14~2022.11.20
CNS刊登文章
Nature
本周无
Science
本周无
01
Cell
2022/11/18
“A Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization”
先天性寨卡病毒（ZIKV）感染导致高达14%的感染ZIKV母亲所生婴儿的神经发育缺陷。中和抗体是保护性免疫的关键组成部分。来自美国国立卫生研究院的Mattia Bonsignori以及康奈尔医学院的Sallie R. Permar团队合作证明血浆IgM有助于妊娠期ZIKV免疫，在出现症状后3个月内介导中和反应。从一名感染ZIKV的孕妇中，研究者分离出一种五聚体ZIKV的特异性IgM（DH1017.IgM），其表现出依赖于IgM同型的超强ZIKV中和作用。DH1017.IgM靶向病毒包膜的结构域II形成的二聚体表位。病毒上的表位排列与DH1017.IgM的所有十个抗原结合位点的同时结合相兼容。相比于之前只有IgG表达时，DH1017.IgM在致命ZIKV攻击时更有效的保护小鼠对抗病毒血症。本研究确认了IgM同型抗体在预防寨卡病毒感染方面的作用，并确定了DH1017.IgM作为一种安全有效的候选免疫疗法，特别是在怀孕期间。
原文链接
https://www.cell.com/cell/fulltext/S0092-8674(22)01369-1
2022.11.14~2022.11.20
子刊刊登文章
Cell Research
本周无
Molecular Cell
本周无
01
Nature Structural & Molecular Biology
11.17
“Structure determination of inactive-state GPCRs with a universal nanobody”
02
Nature Communications
11.14
1.“Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity”
11.14
2.“An extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation”
11.14
3.“Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase”
11.14
4.“Conformational motions and ligand-binding underlying gating and regulation in IP3R channel”
11.14
5.“Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel”
11.15
6.“Structure of the reduced microsporidian proteasome bound by PI31-like peptides in dormant spores”
11.16
7.“Understanding VPAC receptor family peptide binding and selectivity”
11.16
8.“Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex”
11.16
9.“CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder”
11.17
10.“Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation”
11.17
11.“Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter”
11.17
12. “Activation and signaling mechanism revealed by GPR119-Gs complex structures”
11.18
13.“Donor-strand exchange drives assembly of the TasA scaffold in Bacillus subtilis biofilms”
11.18
14.“Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones”
11.18
15.“A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1”
11.18
16.“Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus”
11.19
17.“Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state”
11.19
18.“DNA mechanical flexibility controls DNA potential to activate cGAS-mediated immune surveillance”
11.19
19.“Deep learning to decompose macromolecules into independent Markovian domains”
11.19
20.“Structural and functional asymmetry of RING trimerization controls priming and extension events in TRIM5α autoubiquitylation”
11.19
21.“PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation”
11.19
22.“Structure of the human heparan sulfate polymerase complex EXT1-EXT2”
03
Science Advances
11.16
“Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling”
转自：“北京生物结构前沿研究中心”微信公众号
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