美国路易斯维尔大学张皇阁课题组诚聘博士后

Postdoctoral associate positions are available in the laboratory of Dr. Huang-Ge Zhang in the Brown Cancer Center at the University of Louisville, Kentucky, USA.

We are seeking a full-time post-doctoral researcher for a 5-year NIH-funded project aiming to develop edible plant exosomes like nanoparticles (ELNs) based immune therapy for cancer and autoimmune disease. The lab also explores the cellular and molecular mechanisms by which the ELNs inhibit cancer to advance and brain neurodegeneration, emphasizing gut microbiota metabolites mediated cancer metastasis, microglial mitochondrial pathology, metabolism, and immune response. We use a combination of in vitro cell culture, in vivo transgenic/knockout animal models.

Required Qualifications:                                                               

A PhD or MD degree in immunology, biochemistry, molecular biology, microbiology or other medical research related fields is required. Previous working experience in mouse models, mitochondria, microbiome, and nanoparticles involving the brain, liver, lung or gutdisease is highly desired.

Commensurate with experience. Provide competitive salary with excellent fringe benefits. The living cost in Louisville is very affordable.

Interested individuals should send a cover letter, CV, and the names/phone numbers of three people who could provide letters of reference by email to:

Huang-Ge Zhang, h0zhan17@louisville.edu or yun.teng@louisville.edu

The major publications (selected) from 134 in Dr. Huang-Ge Zhang’s team

• Gut Bacterial Isoamylamine Promotes Age-Related Cognitive Dysfunction by Promoting Microglial Cell Death. Cell Host & Microbe, 2022 June.

• Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway. EMBO report. 2022 Jan.

• High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance, Nature Communications, 2021 Dec 12:213

• Restoring Oat Nanoparticles Mediated Brain Memory Function of Mice Fed Alcohol by Sorting Inflammatory Dectin-1 Complex into Microglial Exosomes, Small, 2021 Dec 13;e2105385

• Plant-derived exosomal microRNAs shape the gut microbiota. Cell Host & Microbe, 2018, Volume 24, Issue 5, 637–652.

• MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression, Nature Communications, 2017 Feb 17;8:14448

• Ginger- derived nanoparticles protect against alcohol-induced liver damage. J Extracell Vesicles. 2015 Nov 25;4:28713. doi: 10.3402/jev.v4.28713.

• Intestinal mucus-derived nanoparticles mediate activation of Wnt/β-catenin signaling plays a role in induction of liver NKT cell anergy. Hepatology. 2013 57(3):1250-61.

• Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids. Nature Communications. 2013;4:1867. doi: 10.1038/ncomms2886.

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