2022/3/24 17:48:21 阅读：373 发布者：chichi77
职位信息
High fidelity computational approaches to exploit new structures of cardiac ion channels
The University of Manchester: Biology, Medicine and Health
Supervisor：Dr Andrew Leach, Dr Luigi Venetucci, Dr Sally Freeman
Application Deadline ：Monday, April 18, 2022
Funded PhD Project (Students Worldwide)
1.
About the Project
Before a new drug can be tested in humans, it is required to undergo testing in animals. A key part of this is to check that the medicine does not cause disruptions or changes to the heart’s regular rhythm. This is usually tested by giving the compound to dogs and at least one other species of animal, even including primates, with monitoring equipment surgically implanted. We want to provide an alternative to these tests that takes place entirely inside a computer. If it works, it will be even better than the animal tests because it will tell researchers how to solve any problem.
The molecular structures of the most relevant ion channels has been recently (2020 and 2021) much better understood thanks to the Cryo-EM technique that won the Nobel prize for chemistry in 2017. In addition, Dr Leach has developed a new way to calculate the strength of interaction between molecules and we propose combining this new method with the new structures to create our alternative to animal tests.
The student would be joining a vibrant research environment that would allow them to work closely with computational and synthetic chemists, as well as biologists and clinicians. In the first phase of their work they will be based in a computational research lab but the project has latitude for them to tailor the later stages to their interests and aspirations and they could work in a chemical laboratory making compounds or with biologists to understand how the compounds have their effect. Ideally, candidates will have a background in the chemical sciences and this project is well suited to those interested in working in drug discovery, medicinal chemistry or toxicology. Students with a background in related disciplines or with a strong motivation to move into this field are encouraged to apply.
2.
Candidate
Applicants are expected to hold (or about to obtain) a minimum upper second class undergraduate honours degree (or equivalent) in the chemical sciences or other relevant discipline. This might include an interest in drug discovery, medicinal, pharmaceutical or computational chemistry, or toxicology. Students with a background in related disciplines or with a strong motivation to move into this field are encouraged to apply. A Masters degree in a relevant subject and/or experience related to drug design and discovery is desirable.
3.
How to apply
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website:
https://www.bmh.manchester.ac.uk/study/research/apply/
You MUST also submit an online application form - choose PhD Drug Design, Development and Delivery.
Applicants interested in this project should make direct contact with the Primary Supervisor to arrange to discuss the project further as soon as possible.
4.
Funding Notes
This project is funded by the National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs). Studentship funding is for a duration of three years to commence in September 2022 and covers UK tuition fees and a UKRI stipend (£16,062 per annum 22/23). This studentship is open to both UK and international applicants. However, we are only able to offer a limited number of studentships to applicants outside the UK. Therefore, full studentships will only be awarded to exceptional quality candidates, due to the competitive nature of this scheme.
如有侵权，请联系本站删除！
