NMR IN BIOMEDICINE
Author Guidelines
Aims and Scope
Article formats
Manuscript submission
Essential information to include with your submission
Writing Abstracts
The anatomy of a research article
Reference Style
Citing EarlyView Articles
Illustrations and ChemDraw Rules
Article Preparation Support
Colour Policy
Copyright and Permissions
Publication ethics
Further Information
Article formats
Research articles
Rapid communications
Reviews
Letters to the editor
Book reviews
Forthcoming events
Research articles. These papers will describe, in detail, original methods and their applications in the fields covered by the journal. Original papers should not include material that has been published elsewhere, except in abstracts. The manuscripts should be organised as follows (consult a recent journal issue for style and format).
Rapid communications. These should not normally exceed four journal pages in length. A letter justifying the request for rapid publication must be included with the manuscript. The content and organisation should follow the guidelines for full papers. Page proofs will not be sent to the authors before publication.
Reviews. These will usually be written at the invitation of the Editors. Unsolicited reviews are welcome but authors wishing to submit a review are requested to consult the Editors prior to commencement.
Letters to the editor. These, which need have no fixed format, are intended for constructive comments on published work or for putting forward new ideas, and are published at the discretion of the Editors.
Book reviews. The Editors will be pleased to receive books for possible review.
Forthcoming events. Please send details to the Editor-in-Chief.
Manuscript Submission
New submissions should be made via the Research Exchange submission portal submission.wiley.com/journal/nbm. Should your manuscript proceed to the revision stage, you will be directed to make your revisions via the same submission portal. You may check the status of your submission at anytime by logging on to https://submission.wiley.com/journal/nbm and clicking the “My Submissions” button. For technical help with the submission system, please review our FAQs or contact submissionhelp@wiley.com.
Parts of the Manuscript
Manuscripts can be uploaded as a single Microsoft Word document (containing the main text, tables and figures), or with figures and tables provided as separate files. Should your manuscript reach revision stage, figures and tables must be provided as separate files. The main manuscript file can be submitted in Microsoft Word (.doc or .docx) or LaTex (.tex) formats.
If submitting your manuscript file in LaTex format via Research Exchange, select the file designation “Main Document – LaTeX .tex File” on upload. When submitting a Latex Main Document, you must also provide a PDF version of the manuscript for Peer Review. Please upload this file as “Main Document - LaTeX PDF.” All supporting files that are referred to in the Latex Main Document should be uploaded as a “LaTeX Supplementary File.”
Cover Letters and Conflict of Interest statements may be provided as separate files, included in the manuscript, or provided as free text in the submission system. A statement of funding (including grant numbers, if applicable) should be included in the “Acknowledgements” section of your manuscript.
Authorship
On initial submission, the submitting author will be prompted to provide the email address and country for all contributing authors.
Note:
The journal to which you are submitting your manuscript employs a plagiarism detection system. By submitting your manuscript to this journal you accept that your manuscript may be screened for plagiarism against previously published works
Data Protection
By submitting a manuscript to or reviewing for this publication, your name, email address, and affiliation, and other contact details the publication might require, will be used for the regular operations of the publication, including, when necessary, sharing with the publisher (Wiley) and partners for production and publication. The publication and the publisher recognize the importance of protecting the personal information collected from users in the operation of these services, and have practices in place to ensure that steps are taken to maintain the security, integrity, and privacy of the personal data collected and processed. You can learn more at https://authorservices.wiley.com/statements/data-protection-policy.html.
GUIDELINES FOR COVER SUBMISSIONS
If you would like to send suggestions for artwork related to your manuscript to be considered to appear on the cover of the journal, please follow these general guidelines follow these general guidelines.
Essential information to include with your submission
Publication details: The following information must be included in your submitted manuscript:
a word count on the first page of the article
The name(s) of any sponsors of the research contained in the paper, along with grant numbers.
Up to eight keywords that describe your paper for indexing purposes.
A list of abbreviations used, excluding standard abbreviations.
Writing Abstracts
Articles submitted to NMR in Biomedicine must be accompanied by 2 different types of abstract. 1) A graphical abstract and 2) an abstract summary. A graphical abstract is an ‘at a glance’ textual and graphical preview of your article presented in the journals’ table of contents.
The abstract summary is a text only, 300 word overview of the research presented at the head of the article.
Graphical abstract. Supply the following material for the Graphical Abstract on a separate page: the full title, the names of the authors, a short abstract of not more than 80 words or 3 sentences of text summarising the key findings presented in the paper, and one figure. These should be submitted to Manuscript Central in one of the generic file formats and uploaded as ‘Supplementary material for review’ during the initial manuscript submission process. The image supplied should fit within the dimensions of 50mm x 60mm, and be fully legible at this size. Examples for arranging the text and figures as well as paper title and authors' names are shown below.
Abstract summary. An abstract summary is a concise overview of the whole paper, not just the conclusions. The abstract should be no more than 300 words and convey the following: 1. An introduction to the work. This should be accessible by scientists in any field and express the necessity of the experiments executed, 2. Some scientific detail regarding the background to the problem, 3. A summary of the main result, 4. The implications of the result, 5. A broader perspective of the results, once again understandable across scientific disciplines. It is crucial that the abstract convey the importance of the work and be understandable without reference to the rest of the manuscript. Abstracts should not contain any citation to other published works.
The anatomy of a research article
Introduction. For the reader's benefit, a concise background summary of the subject material should be presented, concentrating on the specific aspects that have led to the current report (purpose, goals), with citation of important previous work and useful review articles. Lengthy repetition of 'common' knowledge or an in-depth literature review is not appropriate.
Experimental.All necessary information should be given to completely describe the system under investigation. Technical information and methodologies should be presented in sufficient detail so that a thorough evaluation of the meaning and accuracy of the work can be made and the experiments can be repeated by others. References may be made to previously published work that presents directly relevant details (e.g. preparation and purification procedures, cell culture details, pulse sequences). However, it should be possible to understand and form a critical judgement of the current work without extensive recourse to the literature.
For example, for animal studies procedures for maintaining and/or monitoring anaesthesia, body temperature, blood pressure, and blood gases are of interest. For cell culture work details concerning the medium, serum type and concentration, substrate material (flask type and size), atmospheric composition, pH, medium volume and change interval, and harvesting procedures should be provided. Animal strains, cell culture lines, chemicals and drugs (including generic names), doses, routes of administration, etc. should be precisely defined. Sources should be defined (company or institution, city, state (USA) and country). The work must have met local ethical and legal standards. For MRS, chemical shifts should be referenced to a commonly used standard; for external standards (e.g. in a capillary) the precise composition of the reference and the geometry should be defined.
The following information regarding MR measurements should be included wherever appropriate:
MR instrumentation: manufacturer and model; magnetic field strength in T; bore size and orientation (horizontal or vertical); designation of probehead type, shim and gradient systems, computer system and software.
For non-standard probeheads and for in vivo work for imaging, further details concerning rf coil or resonator configurations should be supplied. For asymmetric samples, give the orientation of the long axis with respect to the B 0 field and the orientation of the coil configuration with respect to the sample.
Hardware efficiency and calibrations should be defined as completely as possible, e.g. rf: transmitter and decoupler powers, pulse length for 90° or 180° pulses (e.g. at the centre of a surface coil); field gradients: max. strength used in mT/m, efficiency in mT/m/A (when known), was pre-emphasis used, min. dead time.
Commonly used pulse sequences should be defined by the accepted name; modified or more specialised sequences should be clearly presented or a literature reference given. The timing of all sequences should be completely defined in terms of the delays and pulse lengths used (including gradients). Specify the total measurement time required for each experiment. In multidimensional studies the spatial and frequency domains and the phase-encoding and rf phase-cycling schemes should be defined. For 2D MRS the following points are of interest: spectral width, time increments, and number of data points in each time domain; techniques for quadrature detection and digitisation (sequential or simultaneous); phase cycling or gradient-echo techniques for selection of coherence transfer pathways, magnitude or phase-sensitive mode.
Where appropriate, define TR and TE, their relationship to relaxation times, and correction factors used for quantitative analysis.
Fourier transformation methods should be clearly defined in terms of window functions (appodization) used, zero-filling, final data sizes in each dimension, modes and algorithms used (magnitude or phase-sensitive, real or complex).
Methods of data processing and analysis and software packages used should be clearly defined. The use of established statistical methods is encouraged when making comparisons or defining trends and dependencies. For linear regression analysis the correlation coefficient r is required, and when the regression coefficient (slope) b is used, its estimated standard error should be given; from these parameters a t - or F -test for the significance of a correlation can be made. For a general least-squares fit the mean squared residuals and the standard errors for fitted parameters should be given. When a t -test is used, the type of comparison being made or the 'null' hypothesis for which p values will be quoted should be described (e.g. two-sample comparison of means, one sample t statistic for comparing one value to a sample mean, confidence level analysis, etc); always specify whether a one or two-sided test is applied and for a two-sample test specify whether equal variances for the two groups (e.g. large populations with n > 5) or unequal variances (conservative test more appropriate for small samples of unequal size) have been assumed. Note that the F -test for equal variances can be misleading for non-normal or skewed distributions. A critical discussion of these tests can be found in Introduction to the Practice of Statistics by D.S. Moore and G.P. McCabe (W.H. Freeman & Co., 1989). Other useful texts are: Statistics: A Biomedical Introduction, B.W. Brown Jr and M. Hollander (John Wiley & Sons, 1977) and Introduction to Probability and Statistics, 7th Ed., W. Mendenhall (Duxbury Press, 1989).
Results. The most important original data and findings should be presented in a logical sequence, using the minimum number of tables and figures necessary for clarity and completeness. Representative spectra or images should be included as necessary to demonstrate the quality of the primary data and the strength of the conclusions drawn. Avoid lengthy explanations or comparisons that are redundant with the Experimental or Discussion sections.
Discussion. This section is reserved for the presentation of justifiable conclusions based on the material in the Results section, for comparisons with previous work, and for the discussion of implications. Where appropriate, alternative interpretations should be considered and ruled out if possible. If preferred, the Results and Discussion may be combined.
Acknowledgements. These should be brief and placed at the end of the paper.
Units and Symbols. In general SI units should be used, but blood pressures should be given in mmHg. Concentrations in vivo should be described where possible in molar terms, e.g. mmol/kg wet wt. M should be used for mol/L. (The letter M is not an abbreviation for mole, it is reserved for molar. Use mM for 10 -3 mol/L and µM for 10 -6 mol/L). Unusual symbols should be defined on first use.
Abbreviations. Common abbreviations (e.g. NMR, MRS, MRI, Pi, TE, TR, T1, T2, ATP etc) may be used without definition. The IUPAC nomenclature for chemical names and abbreviations should be used as first choice (e.g. phosphocholine, not phosphorylcholine; Glc for glucose, not Glu or Gluc), e.g. Eur. J. Biochem. 1970; 15: 203-308; 1977; 79 : 1-21, and Biochem. J. 1996; 313: 4-15. A list of non-standard abbreviations should be included. Acronyms e.g. for pulse sequences, are acceptable in principle, subject to their relevance/value/elegance/wit.
Supplementary Material. Authors may submit supplementary material alongside their manuscript. This facility should be used for data or results which are too detailed or lengthy to appear in the manuscript, but which might nevertheless be of interest to other researchers. On acceptance of the manuscript the supplementary material will be made available on the NBM website, and an indication that additional material is available will be included in the paper.
……
更多详情：
https://analyticalsciencejournals.onlinelibrary.wiley.com/hub/journal/10991492/homepage/forauthors.html
